Open AccessCurcumin alleviates inflammation in Takayasu's arteritis by blocking CCL2 overexpression in adventitial fibroblasts
Author(s) -
Sheng Wu,
Xiaoni Kong,
Yujiao Wang,
XiaoYong Fan,
Qingrong Huang,
Rongyi Chen,
Wandong Yu,
Lili Ma,
Ying Sun,
Lindi Jiang
Publication year - 2021
Publication title -
clinical and experimental rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 95
eISSN - 1593-098X
pISSN - 0392-856X
DOI - 10.55563/clinexprheumatol/72an1a
Subject(s) - medicine , curcumin , adventitia , ccl2 , protein kinase b , inflammation , chemokine , pharmacology , signal transduction , chemistry , biochemistry
Takayasu's arteritis (TAK) is a chronic inflammatory disease with several challenges in treatment. Curcumin is known for its anti-inflammatory effects, whereas its effect in the treatment of TAK remains unclear. In this study, we aimed to investigate the effect of curcumin in the treatment of TAK and its underlying mechanisms.