Open AccessTIM-3 regulates the NETs-mediated dendritic cell activation in myeloperoxidase-ANCA-associated vasculitis
Author(s) -
Bintao Su,
Xinru Mao,
Botao Yin,
Chao Chen,
Meirong Zhang,
Tengfei Cui,
Yi Hao
Publication year - 2021
Publication title -
clinical and experimental rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 95
eISSN - 1593-098X
pISSN - 0392-856X
DOI - 10.55563/clinexprheumatol/6y0bjb
Subject(s) - myeloperoxidase , neutrophil extracellular traps , medicine , immunology , dendritic cell , autoantibody , toll like receptor , tlr4 , immune system , microbiology and biotechnology , inflammation , innate immune system , antibody , biology
T cell immunoglobulin and mucin domain 3 (TIM-3) has been reported as an important regulatory molecule on T cells and plays a pivotal role in autoimmune diseases, but the impact on dendritic cells (DCs) is poorly explored. The formation of neutrophil extracellular traps (NETs) is considered as strongly implicated in the pathogenesis of autoimmune diseases, such as in myeloperoxidase-antineutrophil cytoplasmic autoantibody associated vasculitis (MPO-AAV). This study thus aimed to investigate the potential regulation roles of TIM-3 in the regulation of NETs-mediated DC activation in MPO-AAV.