Open AccessMyomiRs in cultured muscle cells from patients with idiopathic inflammatory myopathy are modulated by disease but not by 6-month exercise training
Author(s) -
Nikoleta Alchus Laiferová,
Michal Nemec,
Lucia Vernerová,
Mária Balážová,
M. Vokurková,
Sabína Oreská,
Martin Klein,
Maja Špiritović,
Michal Tomčík,
Jiří Vencovský,
Jozef Ukropec,
Barbara Ukropcová
Publication year - 2022
Publication title -
clinical and experimental rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 95
eISSN - 1593-098X
pISSN - 0392-856X
DOI - 10.55563/clinexprheumatol/69z7za
Subject(s) - myogenesis , medicine , endocrinology , oxidative phosphorylation , myocyte , muscle biopsy , myopathy , biology , biopsy , biochemistry
Idiopathic inflammatory myopathies/IIM are associated with changes in muscle-specific microRNA/miR. Exercise improves muscle function and metabolism in parallel with changes in miR expression. We investigated the effects of disease and exercise on miRs in differentiated muscle cells/myotubes from IIM patients and controls.