Open AccessImprovement of microangiopathy after haematopoietic stem cell transplantation in systemic sclerosis
Author(s) -
Maaike Boonstra,
Jacopo Ciaffi,
D. Christine Noordhoek,
Su-San Liem,
Liesbeth J J Beaart-van de Voorde,
Sandra T. A. van Bijnen,
Tom W J Huizinga,
Madelon C. Vonk,
Jeska K de Vries-Bouwstra
Publication year - 2022
Publication title -
clinical and experimental rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.184
H-Index - 95
eISSN - 1593-098X
pISSN - 0392-856X
DOI - 10.55563/clinexprheumatol/5rjvkc
Subject(s) - medicine , microangiopathy , hematopoietic stem cell transplantation , scleroderma (fungus) , thrombotic microangiopathy , transplantation , gastroenterology , immunosuppression , surgery , pathology , diabetes mellitus , disease , endocrinology , inoculation
Haematopoietic stem cell transplantation (HSCT) is a treatment option for patients with severe systemic sclerosis (SSc), but the efficacy of the procedure in remodelling the nailfold microvascular array is largely unknown. Therefore, this study aimed to evaluate the effect of HSCT on microangiopathy assessed through nailfold capillaroscopy (NC) and to compare the results with findings in patients receiving conventional immunosuppression.