Open AccessPreparation and characterization of a fluocinolone acetonide nanoemulsion as a topical delivery system
Author(s) -
Katyan Kanishk,
Raj Pal Sharma,
Aruna Sharma
Publication year - 2022
Publication title -
journal of medical pharmaceutical and allied sciences
Language(s) - English
Resource type - Journals
ISSN - 2320-7418
DOI - 10.55522/jmpas.v11i1.2118
Subject(s) - fluocinolone acetonide , emulsion , chemistry , solubility , chromatography , pulmonary surfactant , triamcinolone acetonide , peg 400 , absorption (acoustics) , dermatology , organic chemistry , materials science , medicine , polyethylene glycol , surgery , biochemistry , composite material
The objective of current research project is to characterize and formulate nano-emulsion of Fluocinolone-acetonide as an efficacious treatment for atopic dermatitis. Fluocinolone-acetonide is a synthetic hydrocortisone derivative used in dermatology to reduce inflammation of skin. It categorize under BCS class II i.e. low solubility and high penetrability. Solubility is low and absorption rate is very minimal. Consequently, to overcome these issues nano-emulsions have been formulated. Topical nano-emulsion containing 0.01% Fluocinolone-acetonide with several oils (castor oil, olive oil, almond oil and oleic acid), surfactant (Tween 20, Tween 80), co-surfactant (PEG 400, PEG 200) and distilled water. Several water-in-oil nano-emulsion were formulated by ultra-sonication method. Nano-emulsion formulations were characterized for thermodynamic stability test, pH, viscosity, FTIR and in-vitro drug release study and stability studies. Keywords: Nanoemulsion, Atopic dermatitis, Solubility, Absorption, Fluocinolone acetonide.