A case report of prucalopride treatment in pediatric gastroparesis: a novel therapy | Zendy

Diana Paola Escobar-Serna | Zendy; Fernando Javier Peralta-Palmezano | Zendy; Juan Javier Peralta-Palmezano | Zendy

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A case report of prucalopride treatment in pediatric gastroparesis: a novel therapy

Author(s) -

Diana Paola Escobar-Serna,

Fernando Javier Peralta-Palmezano,

Juan Javier Peralta-Palmezano

Publication year - 2022

Publication title -

archivos argentinos de pediatria

Language(s) - English

Resource type - Journals

eISSN - 1668-3501

pISSN - 0325-0075

DOI - 10.5546/aap.2022.eng.e98

Subject(s) - medicine , gastroparesis , gastric emptying , gastroenterology , metoclopramide , domperidone , scintigraphy , anesthesia , vomiting , stomach , dopamine

Prucalopride has been used in adults with gastroparesis, accelerating gastric emptying. There are no studies with this drug in gastroparetic children. An 8-year-old boy is presented who consulted for a month of postprandial symptoms, with a diagnosis of gastroparesis by gastric emptying scintigraphy. He did not improve with metoclopramide, domperidone, erythromycin, and esomeprazole. He received prucalopride for two periods (for 178 and 376 days) at doses: 0.03 - 0.04 mg/ kg/day, presenting improvement in the follow-up with the cardinal gastroparesis symptom index and gastric emptying scintigraphy. Due to the good response, prucalopride may be a therapeutic option in pediatric gastroparesis.

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