Open AccessDetermination of a new constant to estimate glomerular filtration rate in pediatrics
Author(s) -
Melina Porporato,
Elsa Isern,
M. Pellegrini,
Paula M Carlopio,
Jorgelina M Becchio,
Mariela Ríos,
María B Irigoyen,
Fabiana Vonmaro,
Diana Massó
Publication year - 2021
Publication title -
archivos argentinos de pediatría
Language(s) - English
Resource type - Journals
eISSN - 1668-3501
pISSN - 0325-0075
DOI - 10.5546/aap.2021.eng.e428
Subject(s) - renal function , creatinine , urology , urine , medicine , linear correlation , chemistry , linear relationship , endocrinology , mathematics , statistics
In pediatrics, glomerular filtration rate (GFR) may be estimated by measured corrected creatinine clearance (mcCrCl) (mL/min/1.73 m2) or the Schwartz formula (eGFR = height/plasma creatinine x k). The constant k depends on the plasma creatinine determination method: k = 0.55 for the Jaffe colorimetric method and k = 0.413 for the enzymatic method. Our laboratory uses the compensated kinetic colorimetric assay (CKC), and differences are observed between the estimated and measured GFR. Hypothesis: The proposed values of k do not adjust to the CKC method for plasma creatinine.