Open AccessSurvival of pediatric patients with primary immunodeficiencies in a public hospital in western Mexico
Author(s) -
María NúñezNúñez,
Juan Carlos Lona-Reyes,
Sandra I Cortés-González,
Regina M Navarro-Martin del Campo,
Ana L Orozco-Alvarado,
Óscar González-Ramella,
Luis Gustavo Orozco-Alatorre
Publication year - 2021
Publication title -
archivos argentinos de pediatría
Language(s) - English
Resource type - Journals
eISSN - 1668-3501
pISSN - 0325-0075
DOI - 10.5546/aap.2021.eng.202
Subject(s) - medicine , pediatrics , immunity , immunology , immune system
A case series of primary immunodeficiencies is presented and outcome measures associated with survival among patients ≤ 16 years old are described. Diagnoses were made based on the criteria by the International Union of Immunological Societies. Survival was analyzed using Kaplan-Meier curves. Between 2004 and 2019, 40 patients were diagnosed with primary immunodeficiencies. The most common were immunodeficiencies affecting humoral and cell-mediated immunity (32.5 %) and predominantly antibody deficiencies (32.5 %). The median age at the onset of symptoms and at the time of diagnosis was 3.01 and 10.4 months, respectively. Thirty-five percent of patients died, and the risk was higher among those with immunodeficiencies affecting humoral and cell-mediated immunity and those who developed clinical manifestations and were diagnosed in the first 6 months of life.