Open AccessRespuesta al lenvatinib en una paciente pediátrica con insuficiencia respiratoria secundaria a carcinoma papilar de tiroides
Author(s) -
Noelia Dujovne,
María B Lucero,
Natalia Gazek,
Fabián Pitoia,
Laura Felipe,
Víctor Ayarzabal,
Jessica López Martí,
Marta Ciaccio,
Viviana Herzovich
Publication year - 2021
Publication title -
archivos argentinos de pediatría
Language(s) - Spanish
Resource type - Journals
eISSN - 1668-3501
pISSN - 0325-0075
DOI - 10.5546/aap.2021.e70
Subject(s) - medicine , lenvatinib , thyroid cancer , total thyroidectomy , papillary thyroid cancer , papillary carcinoma , thyroid carcinoma , thyroid , surgery
Papillary thyroid cancer is the most common thyroid tumor in childhood. In advanced stages, it can present with respiratory failure. The treatment of choice is total thyroidectomy and radioactive iodine. In cases of unresectable tumors, therapy with multikinase inhibitors should be considered. A 10-year-old girl was referred for progressive respiratory failure. A diagnosis of papillary thyroid cancer with pulmonary metastases was made. Due to the presence of an unresectable tumor not subject to surgery, the compassionate use of lenvatinib was indicated, showing a rapid and favorable clinical response with resolution of respiratory failure on the ninth day. Early diagnosis of papillary thyroid cancer prevents severe respiratory morbidity caused by late diagnoses. The use of lenvatinib should be considered as a previous step towards first-line therapies (surgery and radioactive iodine) in cases with great local and distant involvement.