Open AccessInfecciones por serratia, ¿debemos pensar en inmunodeficiencias primarias?
Author(s) -
Alicia Montaner Ramón,
Laura Murillo Sanjuán,
Cristina Martínez Faci,
C. Guerrero Laleona,
Carmen Rodríguez-Vigil Iturrate
Publication year - 2017
Publication title -
archivos argentinos de pediatría
Language(s) - Spanish
Resource type - Journals
SCImago Journal Rank - 0.236
H-Index - 19
eISSN - 1668-3501
pISSN - 0325-0075
DOI - 10.5546/aap.2017.e108
Subject(s) - medicine , anamnesis , chronic granulomatous disease , serratia , primary immunodeficiency , humanities , immunodeficiency , serratia marcescens , pediatrics , immunology , disease , biology , bacteria , escherichia coli , immune system , pseudomonas , philosophy , genetics , biochemistry , gene
Chronic granulomatous disease (CGD) is a primary immunodeficiency with an incidence of 1/200,000-250,000 live births. CGD affects mainly male patients, most of the mutations being X-linked, and autosomal recessive forms occur more frequently in communities with greater numbers of consanguineous marriages. CGD is characterized by sensitivity to recurrent and severe bacterial and fungal infections, with formation of granulomas due to the inability of phagocytes to generate reactive oxygen compounds, necessary for the intracellular death of phagocytic microorganisms. We report three cases of CGD in which Serratia marcescens was isolated, and after detailed anamnesis and performance of neutrophil function tests, a molecular diagnosis of the disease was reached. CGD can be manifested in a wide variety of ways, so that high suspicion and a meticulous anamnesis are essential to reach a diagnosis.