Hipogonadismo hipogonadotropo en paciente con síndrome de Klinefelter y tumor hipotálamo- hipofisario | Zendy

Anunciación Beisti Ortego | Zendy; Antonio De Arriba Muñoz | Zendy; Marta Ferrer Lozano | Zendy; José Miguel Martínez de Zabarte Fernández | Zendy; Carlota Calvo Escribano | Zendy; José Ignacio Labarta Aizpún | Zendy

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Hipogonadismo hipogonadotropo en paciente con síndrome de Klinefelter y tumor hipotálamo- hipofisario

Author(s) -

Anunciación Beisti Ortego,

Antonio De Arriba Muñoz,

Marta Ferrer Lozano,

José Miguel Martínez de Zabarte Fernández,

Carlota Calvo Escribano,

José Ignacio Labarta Aizpún

Publication year - 2014

Publication title -

archivos argentinos de pediatria

Language(s) - Spanish

Resource type - Journals

SCImago Journal Rank - 0.236

H-Index - 19

eISSN - 1668-3501

pISSN - 0325-0075

DOI - 10.5546/aap.2015.e6

Subject(s) - luteinizing hormone , hypergonadotropic hypogonadism , medicine , klinefelter syndrome , hormone , endocrinology , follicle stimulating hormone

Klinefelter Syndrome is the most frequent cause of hypergonadotropic hypogonadism in men. A flat response at luteinizing hormone releasing hormone stimulation test could be the first sign of hypothalamic tumor in these patients. We report the case of a patient diagnosed by neonatal screening with Klinefelter Syndrome, 47 XXY, that at 17 years follow-up presents analytical modification of the response to luteinizing hormone releasing hormone stimulation test with suppressed luteinizing hormone and follicle-stimulating hormone values; lately he presents with headache and loss of left eye vision. A magnetic resonance imaging of the brain showed a mixed germ cell hypothalamus tumor, requiring surgery, chemotherapy and radiotherapy with optimal response.

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