Falla hepática secundaria a toxicidad por tuberculostáticos. Caso clínico | Zendy

Ivone Malla | Zendy

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Falla hepática secundaria a toxicidad por tuberculostáticos. Caso clínico

Author(s) -

Ivone Malla

Publication year - 2012

Publication title -

archivos argentinos de pediatria

Language(s) - Spanish

Resource type - Journals

eISSN - 1668-3501

pISSN - 0325-0075

DOI - 10.5546/aap.2012.e35

Subject(s) - pyrazinamide , isoniazid , medicine , drug , liver transplantation , gastroenterology , liver failure , orthotropic material , pharmacology , surgery , tuberculosis , transplantation , pathology , physics , finite element method , thermodynamics

Hepatoxicity of isoniazid, mainly in association with rifampin, is a rare secondary effect of tuberculostatic treatment. In the United States, it accounts for 0.2% of all pediatric orthotropic liver transplant, and 14% of transplants for drug hepatotoxicity. We report the case of a 10 year-old patient who presented with acute liver failure requiring orthotropic liver transplant after forty days of tuberculostatic treatment with isoniazid, rifampin and pyrazinamide.

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