Open AccessFalla hepática secundaria a toxicidad por tuberculostáticos. Caso clínico
Author(s) -
Ivone Malla,
Martín Fauda,
Enrique Casanueva,
M. Isabel Fernández,
Marcelo Amante,
Yu Cheang,
G. Giacove,
Alejandra Pedreira,
Pablo Petracca,
Ariel González Campaña,
Marcelo Silva,
Gustavo Podestá
Publication year - 2012
Publication title -
archivos argentinos de pediatría
Language(s) - Spanish
Resource type - Journals
eISSN - 1668-3501
pISSN - 0325-0075
DOI - 10.5546/aap.2012.e35
Subject(s) - pyrazinamide , isoniazid , medicine , drug , liver transplantation , gastroenterology , liver failure , orthotropic material , pharmacology , surgery , tuberculosis , transplantation , pathology , physics , finite element method , thermodynamics
Hepatoxicity of isoniazid, mainly in association with rifampin, is a rare secondary effect of tuberculostatic treatment. In the United States, it accounts for 0.2% of all pediatric orthotropic liver transplant, and 14% of transplants for drug hepatotoxicity. We report the case of a 10 year-old patient who presented with acute liver failure requiring orthotropic liver transplant after forty days of tuberculostatic treatment with isoniazid, rifampin and pyrazinamide.