Open AccessLesión renal aguda secundaria a lisis tumoral inducida por esteroides en una adolescente con leucemia linfoblástica aguda. Rol de la alcalinización urinaria y diálisis peritoneal
Author(s) -
Gustavo Roberto Marín
Publication year - 2012
Publication title -
archivos argentinos de pediatría
Language(s) - Spanish
Resource type - Journals
SCImago Journal Rank - 0.236
H-Index - 19
eISSN - 1668-3501
pISSN - 0325-0075
DOI - 10.5546/aap.2012.e118
Subject(s) - medicine , nephrocalcinosis , tumor lysis syndrome , peritoneal dialysis , lymphoblastic leukemia , acute kidney injury , urinary system , tubulopathy , gastroenterology , kidney disease , kidney , leukemia , chemotherapy
An adolescent with acute lymphoblastic leukemia developed an early and severe tumor lysis syndrome with acute kidney injury after a low and single dose of steroids. Renal dysfunction was attributed primarily to phosphate nephropathy with nephrocalcinosis due to extreme elevations of phosphate in blood. Urinary alkalinization probably contributed to this development. We used peritoneal dialysis with resolution of nephrocalcinosis and normalization of creatinine clearance.