Open AccessAnalysis of risk factors for antipsychotic-resistant schizophrenia in young patients – A retrospective analysis
Author(s) -
O. Vasiliu,
D. Vasile,
Andreea F. Făinărea,
Mihaela C. Pătrașcu,
Elena A. Morariu,
Raluca Manolache,
Iulia Alexandru,
Flavius T. Androne
Publication year - 2018
Publication title -
romanian journal of military medicine
Language(s) - English
Resource type - Journals
eISSN - 2501-2312
pISSN - 1222-5126
DOI - 10.55453/rjmm.2018.121.1.4
Subject(s) - schizophrenia (object oriented programming) , positive and negative syndrome scale , retrospective cohort study , medicine , antipsychotic , multivariate analysis , psychiatry , univariate analysis , medical record , quality of life (healthcare) , clinical psychology , psychology , psychosis , nursing
Treatment resistant schizophrenia (TRS) is a severely disabling disorder, which decreases dramatically the quality of life and overall functionality, while it increases the rate of hospital admissions and overall healthcare costs. The main objective of this research was to evaluate the risk factors for TRS in a group of patients based on a retrospective analysis. The secondary objective was to design an algorithm for initial evaluation in patients with schizophrenia, in order to detect the candidates at risk for developing TRS. Medical charts and consultation records of all patients aged between 18 and 30, diagnosed with TRS, evaluated during 1-year in our department, were selected for analysis. The most significant risk factors for TRS found in univariate model were younger age at schizophrenia onset, male gender, living in rural areas, co-morbid drug dependence, lower therapeutic adherence, and premorbid personality disorder. Marginally significant were higher Positive and Negative Syndrome Scale (PANSS) scores at previous admissions, higher scores on PANSS negative symptoms sub-scale, and lower educational background. In the multivariate model, TRS was still significantly predicted.