Open AccessDiagnostic difficulties in c-kit negative gastrointestinal stromal tumors: report of four cases
Author(s) -
Andreea C. Iorgescu,
Vlad Herlea,
Elena Stoica Mustafa,
C Pechianu,
Alexandru Procop,
Maria Sajin,
Irinel Popescu
Publication year - 2017
Publication title -
romanian journal of military medicine
Language(s) - English
Resource type - Journals
eISSN - 2501-2312
pISSN - 1222-5126
DOI - 10.55453/rjmm.2017.120.3.8
Subject(s) - cd117 , gist , pdgfra , context (archaeology) , medicine , histogenesis , stromal cell , pathology , stromal tumor , immunohistochemistry , cd34 , biology , paleontology , genetics , stem cell
The gastrointestinal stromal tumors (GIST) are dominated by KIT and PDGFRA mutation. The immunohistochemical detection of CD117, a protein express by KIT gene, is essential for the diagnosis and those that are negative always represented a diagnostic challenge Case reports: In this article we present a series of 4 cases of CD117 negative GIST tumors, diagnosed and surgically resected in Fundeni Clinical Institute and an overview of the histogenesis, diagnostic problems and management of c-kit negative GIST. All patients were males and the tumors were located in the stomach and small bowel. Conclusion: It is important for the pathologists to beware of the fact that a CD117 negative in the context of a typical morphological appearance does not exclude a GIST tumor and also the oncologist must be aware not to exclude the therapy with imatinib based on the negativity of CD117.