Open AccessStudy of the type and distribution of tumor infiltrating lymphocytes in 27 cases of lung adenocarcinoma
Author(s) -
Andreea Mihai,
George Simion,
Florin Chirculescu,
Maria Sajin
Publication year - 2017
Publication title -
romanian journal of military medicine
Language(s) - English
Resource type - Journals
eISSN - 2501-2312
pISSN - 1222-5126
DOI - 10.55453/rjmm.2017.120.3.4
Subject(s) - adenocarcinoma , tumor infiltrating lymphocytes , pathology , immunohistochemistry , cyclin d1 , lung cancer , lung , cd8 , cd3 , stroma , medicine , tumor microenvironment , cancer research , cancer , cell cycle , tumor cells , immune system , immunology
Pathologists observed the presence of tumor infiltrating lymphocytes (TILs) in solid tumors many years before the research focus shifted from cancer cells to the tumoral microenvironment. In lung adenocarcinoma TILs vary in number, phenotype and distribution. Our study investigate the type and distribution of TILs regarding the stage of disease and histological subtype in 27 cases of lung adenocarcinoma. By immunohistochemistry we evaluated semi-quantitatively CD3, CD8 and cyclin D1. We have found that CD3+CD8- lymphocytes prevail at the invasive margin and in tumoral stroma. Cyclin D1 was diffusely positive in tumoral cells in all the five cases of lepidic type of lung adenocarcinoma. In other histological types cyclin D1 was focally positive, most at the margin of the tumor irrespective of the presence or absence of TILs.