Open AccessYolk sac tumor in a 20 years old patient
Author(s) -
Ioana A. Negoiță,
Bogdan Panaite,
Ovidiu V. Nicodin,
Dimitrie Nanu
Publication year - 2017
Publication title -
romanian journal of military medicine
Language(s) - English
Resource type - Journals
eISSN - 2501-2312
pISSN - 1222-5126
DOI - 10.55453/rjmm.2017.120.3.10
Subject(s) - yolk sac , endodermal sinus tumor , germ cell tumors , medicine , carboplatin , pathology , immature teratoma , hyaline , etoposide , differential diagnosis , chemotherapy , cisplatin , biology , embryo , microbiology and biotechnology
Yolk sac tumor or endodermal sinus tumor is a rare malignant ovarian germ cell tumor (is a borderline tumor) diagnosed in young females up to 25 years old. Histopathological it resembles the mesenchyme of the primitive yolk sac. Microscopically it presents the following triad: Schiller-Duval bodies, reticular aspect and PAS+ hyaline droplets (α-fetoprotein). The diagnosis of Yolk sac tumor is made by dosing serum α-fetoprotein, ultrasound and MRI – DWI imaging. It requires surgical treatment, followed by chemotherapy (new therapies – platin or carboplatin, etoposide, bleomycin) [1]. Survival prognosis at 5 years is of 80% for stage I. Differential diagnosis is with Brenner tumor, ovarian clear cell carcinoma, dysgerminoma, malignant teratomas, androblastoma, dermoid cyst.