Open AccessDevelopments On 1,2,4-Triazine Scaffold Substitutions For Possible Anticancer Agents
Author(s) -
Vartika John,
Gali Pushpa Raju,
G.J.V.S.N.D. Lakshmi,
Bhavanam Lurdu Rani,
H.B. Bollikolla
Publication year - 2020
Language(s) - English
DOI - 10.55434/cbi.2020.8104
Subject(s) - triazine , moiety , scaffold , ring (chemistry) , chemistry , combinatorial chemistry , stereochemistry , computer science , organic chemistry , programming language
Recent literature studies reveal that heterocyclic scaffolds containing a 1,2,4-triazine ring have gained due significance owing to their pharmacological relevance. This article gives an insight on the different methods used for synthesis of 1,2,4-triazine, its derivatives such as N-oxides, N,N’-dioxides, benzo and hetero-fused systems. The main focus will be on the anti-cancer activities of the 1,2,4-triazine moiety.