Open AccessPolymorphisms of F2 (G20210A), F5 (G1691A), F 7 (G10976A), F 13(G13T), FGB, ITGA2, ITGB3, PAI-I genes and its association with thrombotic complications in patients suffering from Takayasu aortoarteritis of Urals population
Author(s) -
И. Э. Бородина,
Gezel Salavatova,
Lubov Shardina
Publication year - 2021
Publication title -
turk kardiyoloji dernegi arsivi-archives of the turkish society of cardiology
Language(s) - English
Resource type - Journals
eISSN - 1308-4488
DOI - 10.5543/tkda.2021.69741
Subject(s) - thrombophilia , medicine , factor v , factor v leiden , gastroenterology , thrombotic thrombocytopenic purpura , plasminogen activator inhibitor 1 , thrombosis , platelet , immunology , plasminogen activator , venous thrombosis
Cardiovascular complications, especially thrombotic events, are characteristic for Takayasu arteritis (TA). These events significantly deteriorate the patients' quality of life and cause disability and preterm death. Coagulation factor II (F2, G20210A), coagulation factor V (F5, G1691A, Leiden), coagulation factor VII (F7, G10976A), coagulation factor XIII (F13, G13T), fibrinogen (FGB), platelet alpha subunit of transmembrane receptor for collagens and related proteins (ITGA2), platelet glycoprotein (ITGB3), and plasminogen activator inhibitor-1 (PAI-I) gene polymorphisms coexist with TA, and their pathophysiologic interaction needs to be studied.