Open AccessHIV Viral Dynamic under Treatment with Intracellular Delay and Virus Decay as Interactive Parameters
Author(s) -
R. A. C. Prata,
Rosana Sueli da Motta Jafelice,
V. M. Cabral,
F Pedro,
Laécio Carvalho de Barros
Publication year - 2021
Publication title -
trends in computational and applied mathematics
Language(s) - English
Resource type - Journals
ISSN - 2676-0029
DOI - 10.5540/tcam.2021.022.02.00291
Subject(s) - intracellular , virus , viral load , virology , viral replication , viral life cycle , human immunodeficiency virus (hiv) , in vivo , biology , microbiology and biotechnology , genetics
Treatment with antiviral drugs for human immunodeficiency virus type 1 (HIV-1) infection causes a rapid reduction in plasma viral load. Viral decline occurs in several stages and provides information on important kinetic constants of virus replication in vivo and pharmacodynamic properties. We present a mathematical model that not only considers the intracellular phase of the viral life cycle, defined as the time between the infection of a cell and the production of new viral particles, but we also consider that this parameter together with the virus decay are interactive fuzzy numbers.