Open AccessMost systematic structure models of information fusion technology only describe the data processing of information fusion only from the concept, without combining with practical engineering, which cannot effectively the fusion problem in the engineering. Based on the basic idea of information fusion, the information fusion-oriented design method of multiprocessor computer software and hardware is first proposed in this article, combining with the software and hardware design in the practical engineering. The system structure based on the information fusion technology is first established, and the key technology and methods to solve the software and hardware design for information fusion are put forward based on that, and finally, the application of the comprehensive data processing computer proves the effectiveness and feasibility of the system structure and the software design method in the article. The use of the system structure and the software hardware design method proposed in this article can fuse the seemly messy information analysis in the computer system, with stronger data processing capacity, higher reliability, better expansibility and environment adaptability, and create a new way for the research combining the system structure based on the information fusion technology and the practical engineering.