Open AccessOxidase-like Function by Apo-Transferrin towards Manganese(III) Chelates
Author(s) -
Takahiro Satoh,
K. Abe,
Yuzo Nishida
Publication year - 2012
Publication title -
international journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 1916-9701
pISSN - 1916-9698
DOI - 10.5539/ijc.v4n3p10
Subject(s) - chemistry , manganese , transferrin , chelation , ion , inorganic chemistry , nuclear chemistry , biochemistry , organic chemistry
We have observed that oxidation of Mn(III) ion in several manganese chelates to a Mn(IV) state occurs in the presence of apo-transferrin, and at the same time facile up-take of manganese ion by apo-transferrin proceeds. This clearly shows that much manganese ions can be transported to the brain by transferrin under the certain conditions, which may lead to manganism. Based on these results we have prepared the new chelate to capture only the Mn(III) and Mn(IV) ions selectively, but not Mn(II) ion, and to remove these manganese ions from the solution without toxicity