Open AccessOne-pot Preparation of ?–amino Carbonyl Compounds by Mannich Reaction Using MgO/ZrO2 as Effective and Reusable Catalyst
Author(s) -
M Nagrik,
M Ambhore,
Bhumika Gawande
Publication year - 2010
Publication title -
international journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 1916-9701
pISSN - 1916-9698
DOI - 10.5539/ijc.v2n2p98
Subject(s) - chemistry , aldehyde , catalysis , mannich reaction , condensation , organic chemistry , condensation reaction , reaction conditions , combinatorial chemistry , physics , thermodynamics
A new one-pot and efficient three-component condensation of aldehyde, ketones, and amines in the presence of MgO/ZrO2 as an inexpensive and effective catalyst for the synthesis of ?-amino carbonyl compounds by Mannich reaction is described. The present methodology offers several advantages, such as good yields, Short reaction times and a recyclable catalyst with a very easy work up.
Keywords: Multi-component reaction, MgO/ZrO2, heterogeneous catalyst, ?-amino Carbonyl compounds.