One-pot Preparation of ?–amino Carbonyl Compounds by Mannich Reaction Using MgO/ZrO2 as Effective and Reusable Catalyst | Zendy

Deepak M. Nagrik | Zendy; Damodar M. Ambhore | Zendy; Manoj B. Gawande | Zendy

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One-pot Preparation of ?–amino Carbonyl Compounds by Mannich Reaction Using MgO/ZrO2 as Effective and Reusable Catalyst

Author(s) -

Deepak M. Nagrik,

Damodar M. Ambhore,

Manoj B. Gawande

Publication year - 2010

Publication title -

international journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 1916-9701

pISSN - 1916-9698

DOI - 10.5539/ijc.v2n2p98

Subject(s) - chemistry , aldehyde , catalysis , mannich reaction , condensation , organic chemistry , condensation reaction , reaction conditions , combinatorial chemistry , physics , thermodynamics

A new one-pot and efficient three-component condensation of aldehyde, ketones, and amines in the presence of MgO/ZrO₂ as an inexpensive and effective catalyst for the synthesis of ?-amino carbonyl compounds by Mannich reaction is described. The present methodology offers several advantages, such as good yields, Short reaction times and a recyclable catalyst with a very easy work up.

Keywords: Multi-component reaction, MgO/ZrO₂, heterogeneous catalyst, ?-amino Carbonyl compounds.

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