Open AccessRationale: Unlike in adults, stroke is uncommon in children. Even when it occurs, it is commonly haemorrhagic unlike ischemic predominance in adults. There is always a risk factor in childhood stroke. Aim: To present two case reports of childhood ischemic stroke managed conservatively. Case reports: case summary 1: A thirteen year old male Cameroonian Sickle with generalised body weakness, jaundice and right hemiparesis. Brain Computed tomogram (CT) showed premature generalised cerebral and cerebellar atrophy with supervening left parietal lobar ischaemic infarction. Bone window showed widened diploe. Abdomino-pelvic echogram revealed autosplenectomy and choleliathiasis. Case 2: A sixteen month old semi-conscious male Cameroonian with fever and left hemiplegia. Past medical history is Tetralogy of Fallot and Meningitis at 10 month of age. Brain Magnetic resonance imaging (MRI) showed right fronto-parietal cerebral venous infarct due to Superior sagital sinus thrombosis as evidenced by ‘Empty delta sign’. Conclusion: Though stroke in children is uncommon more cases will be discovered with availability of neuro-imagings. The prognosis and prevention of stroke-repeat in Sicklers are better with blood transfusion.