Open AccessBackground: About 16 billion injections are administered each year in developing and transitional countries, most of these are unnecessary and unsafe. Unsafe injection practices including the reuse of needles and syringes are a common public health problem in many countries and contribute to an estimated 40% hepatitis C, 32% hepatitis B and 5% human immunodeficiency virus (HIV) infections each year. The present study was undertaken with two fold objectives to determine the average number of injections per person per year and to assess the level of knowledge and attitudes in relation to injections in a rural population of India. Methodology: A community based cross sectional study was conducted in village located near Nagpur, India. Every alternate house was selected by systematic random sampling. Total 403 houses were served. Any member of the family above 18 yrs of the age and who is residing in the area for more than 6 months and present at the time of visit was interviewed. Statistical Analysis: The data was analyzed using Epi info version 3.4.1 software. Chi-square test was used as test of significance and p value of less than 0.05 was considered as significant Results: A total of 403 families were interviewed. There were 1,109 person-visits to the health care providers in the last 3 months and they received 472 injections, which came out to be 0.23 injection/person/three months. In children below 5 years, 70% of injections were preventive. In 82% of injection use, disposable syringes were used. About 91 % of the respondents were aware about the transmission of some diseases through unclean syringes. More than two-thirds of respondents 69% preferred oral medications to injections. Conclusion: Interventions are needed to improve the safety of injections. These include the introduction of injection devices that prevent reuse, behavioral modification of providers, increasing awareness in the population of risks associated with injection, creating consumer avoidance of injections and demand for safety.