Open AccessNon-human prostate cancer cell lines
Author(s) -
Shantibhusan Senapati,
Subhankar Chakraborty,
I. Nath,
Sasmita Panda,
R. C. Patra,
Surinder K. Batra
Publication year - 2012
Publication title -
oncology, gastroenterology and hepatology reports
Language(s) - English
Resource type - Journals
eISSN - 2348-3113
pISSN - 2278-8921
DOI - 10.5530/ogh.2012.1.5
Subject(s) - prostate cancer , cancer , prostate , medicine , oncology
Cell lines have always been a valuable tool to address a variety of questions related to prostate cancer. Due to
the unavailability of many human prostate cancer cell line models, investigators have shown significant interest
in developing or establishing different new nonhuman prostate cancer cell lines. Indeed, many animal cell line
models have successfully recapitulated key events in human prostate cancer development. For instance, Dunning
rat prostate cancer cell lines have created a system to represent the full spectrum of prostate cancer progression
while canine cell lines like Leo and Ace-1 recapitulate bone metastasis model. The establishment of
in vitro
models of animal cell lines recapitulating human disease will aid in molecular and functional characterization of
human prostate cancer