Open AccessThe Effects of Capparis Spinosa Leaves on The Histological Findings Associated With The Exposure of Mice to Trichloroacetic Acid
Author(s) -
Gharib S. Mahmoud,
Raghed H. Rashed,
Afrah Jabbar Lazim,
Heyam Aziz Mohammed
Publication year - 2022
Language(s) - English
DOI - 10.55145/ajbms.2022.1.1.004
Subject(s) - capparis spinosa , white pulp , red pulp , trichloroacetic acid , hyperplasia , pulp (tooth) , spleen , edema , oral administration , traditional medicine , biology , pathology , medicine , pharmacology , biochemistry
The present work was conducted to study the possible protective role of Capparis spinosa leavesand their efficacy against hematological and histological alterations resulted in an animal model intoxicated withtrichloroacetis acid ( TCA).Hundred male mice 20-26 gm were divided into 5 groups ; control group , group II treated oraly with honey ( 40 mg /Kg body weight for 3 weeks ) , group III treated orally with a mixture of Capparis spinosa leaves powder and honey (40 mg/ Kg for 3 weeks) , group IV treated with TCA in drinking water ( 500 mg / Kg fpr 3 and 6 weeks , then left for3 weeks for recovery) and group V ( Regeneration group ) treated with TCA for 6 weeks then treated with a mixtureof Capparis and honey ( 40 gm /Kg for 3 weeks).Histological examination of spleen sections of mice treated with TCA revealed obvious pathological findingsincluding disorganization of lymphoid follicles , hyperplasia in white pulp , depletion of lymphocyts in red pulpwith subcapsular edema , some necrotic cells in white and red pulp , increasing megakarycoytes, haemosiderosis andfibrosis in red pulp and in some lymphoid follocles. Administration of a mixture of Capparis spinosa leaves powderand honey lessened most of the pathological lesions in mice intoxicated with TCA