Open AccessReview of allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning in solid tumors excluding breast cancer
Author(s) -
Nuri Karadurmuş,
Uğur Şahin,
Bilgin Bahadır Başgöz,
Fikret Arpacı,
Taner Demirer
Publication year - 2016
Publication title -
world journal of transplantation
Language(s) - English
Resource type - Journals
ISSN - 2220-3230
DOI - 10.5500/wjt.v6.i4.675
Subject(s) - medicine , hematopoietic stem cell transplantation , malignancy , transplantation , oncology , refractory (planetary science) , cancer , leukemia , chemotherapy , metastatic breast cancer , stem cell , breast cancer , biology , genetics , astrobiology
Solid tumors in adults constitute a heterogeneous group of malignancy originating from various organ systems. Solid tumors are not completely curable by chemotherapy, even though some subgroups are very chemo-sensitive. Recently, oncologists have focused on the use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) with reduced intensity conditioning (RIC) for the treatment of some refractory solid tumors. After the demonstration of allogeneic graft-versus-leukemia effect in patients with hematological malignancies who received allo-HSCT, investigators evaluated this effect in patients with refractory metastatic solid tumors. According to data from experimental animal models and preliminary clinical trials, a graft-versus-tumor (GvT) effect may also be observed in the treatment of some solid tumors ( e.g ., renal cell cancer, colorectal cancer, etc .) after allo-HSCT with RIC. The use of RIC regimens offers an opportunity of achieving full-donor engraftment with GvT effect, as well as, a reduced transplant-related mortality. Current literature suggests that allo-HSCT with RIC might become a choice for elderly and medically fragile patients with refractory metastatic solid tumors.