Open AccessRole of IL-10 in the progression of kidney disease
Author(s) -
Inna Sinuani,
Ilia Beberashvili,
Zhan Averbukh,
Judith Sandbank
Publication year - 2013
Publication title -
world journal of transplantation
Language(s) - English
Resource type - Journals
ISSN - 2220-3230
DOI - 10.5500/wjt.v3.i4.91
Subject(s) - kidney disease , kidney , cytokine , medicine , disease , acute kidney injury , inflammation , renal stem cell , interleukin , immunology , bioinformatics , biology , microbiology and biotechnology , stem cell , progenitor cell
Interleukin-10 (IL-10), a cytokine with anti-inflammatory and immunomodulatory functions, regulates the biology of B and T cells. The present review describes the role of IL-10 in normal renal physiology, during acute kidney injury and in the development of chronic renal failure. We further discuss IL-10-induced cellular and molecular pathways and their link to the progression of kidney injury.