Open AccessOxidative stress-mediated effects of angiotensin II in the cardiovascular system
Author(s) -
Wen Hu,
Judith K. Gwathmey,
Lai-Hua Xie
Publication year - 2012
Publication title -
world journal of hypertension
Language(s) - English
Resource type - Journals
ISSN - 2220-3168
DOI - 10.5494/wjh.v2.i4.34
Subject(s) - oxidative stress , angiotensin ii , reactive oxygen species , renin–angiotensin system , medicine , homeostasis , hormone , heart failure , endogeny , endocrinology , oxidative phosphorylation , chemistry , biology , microbiology and biotechnology , biochemistry , receptor , blood pressure
Angiotensin II (Ang II), an endogenous peptide hormone, plays critical roles in the pathophysiological modulation of cardiovascular functions. Ang II is the principle effector of the renin-angiotensin system for maintaining homeostasis in the cardiovascular system, as well as a potent stimulator of NAD(P)H oxidase, which is the major source and primary trigger for reactive oxygen species (ROS) generation in various tissues. Recent accumulating evidence has demonstrated the importance of oxidative stress in Ang II-induced heart diseases. Here, we review the recent progress in the study on oxidative stress-mediated effects of Ang II in the cardiovascular system. In particular, the involvement of Ang II-induced ROS generation in arrhythmias, cell death/heart failure, ischemia/reperfusion injury, cardiac hypertrophy and hypertension are discussed. Ca 2+ /calmodulin-dependent protein kinase II is an important molecule linking Ang II, ROS and cardiovascular pathological conditions.