Open AccessWound healing reaction: A switch from gestation to senescence
Author(s) -
María-Ángeles Aller,
Jorge-Luis Arias,
Luis Alfonso Arráez-Aybar,
Carlos Gilsanz,
Jaime Árias
Publication year - 2014
Publication title -
world journal of experimental medicine
Language(s) - English
Resource type - Journals
ISSN - 2220-315X
DOI - 10.5493/wjem.v4.i2.16
Subject(s) - downregulation and upregulation , gastrulation , embryonic stem cell , senescence , microbiology and biotechnology , biology , wound healing , embryogenesis , organism , regeneration (biology) , immunology , pathology , embryo , medicine , genetics , gene
The repair of wounded tissue during postnatal life could be associated with the upregulation of some functions characteristic of the initial phases of embryonic development. The focusing of these recapitulated systemic functions in the interstitial space of the injured tissue is established through a heterogeneous endothelial barrier which has excretory-secretory abilities which in turn, would induce a gastrulation-like process. The repair of adult tissues using upregulated embryonic mechanisms could explain the universality of the inflammatory response against injury, regardless of its etiology. However, the early activation after the injury of embryonic mechanisms does not always guarantee tissue regeneration since their long-term execution is mediated by the host organism.