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Tumor lysis syndrome: A clinical review
Author(s) -
Aibek E. Mirrakhimov
Publication year - 2015
Publication title -
world journal of critical care medicine
Language(s) - Uncategorized
Resource type - Journals
ISSN - 2220-3141
DOI - 10.5492/wjccm.v4.i2.130
Subject(s) - tumor lysis syndrome , rasburicase , medicine , lysis , intensive care medicine , intensive care unit , uric acid , refractory (planetary science) , chemotherapy , immunology , biology , astrobiology
Tumor lysis syndrome is an oncometabolic emergency resulting from rapid cell death. Tumor lysis syndrome can occur as a consequence of tumor targeted therapy or spontaneously. Clinicians should stratify every hospitalized cancer patient and especially those receiving chemotherapy for the risk of tumor lysis syndrome. Several aspects of prevention include adequate hydration, use of uric acid lowering therapies, use of phosphate binders and minimization of potassium intake. Patients at high risk for the development of tumor lysis syndrome should be monitored in the intensive care unit. Established tumor lysis syndrome should be treated in the intensive care unit by aggressive hydration, possible use of loop diuretics, possible use of phosphate binders, use of uric acid lowering agents and dialysis in refractory cases.

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