Open AccessPyruvate-fortified resuscitation stabilizes cardiac electrical activity and energy metabolism during hypovolemia
Author(s) -
Hunaid Gurji,
Daniel W. White,
Besim Hoxha,
Jie Sun,
Albert H. OlivenciaYurvati,
Robert T. Mallet
Publication year - 2013
Publication title -
world journal of critical care medicine
Language(s) - English
Resource type - Journals
ISSN - 2220-3141
DOI - 10.5492/wjccm.v2.i4.56
Subject(s) - medicine , phosphocreatine , resuscitation , ischemia , creatine , creatine kinase , anesthesia , endocrinology , hypovolemia , cardiology , energy metabolism
To test the hypothesis that fluid resuscitation with Ringer's solution enriched with pyruvate (PR), a physiological antioxidant and energy substrate, affords protection of myocardial metabolism and electrophysiological performance superior to lactated Ringer's (LR) during hypovolemia and hindlimb ischemia-reperfusion.