Open AccessNeutrophil kinetics and function after major trauma: A systematic review
Author(s) -
Liam Db Finlay,
Andrew Conway Morris,
Adam M Deane,
Alexander Wood
Publication year - 2021
Publication title -
world journal of critical care medicine
Language(s) - English
Resource type - Journals
ISSN - 2220-3141
DOI - 10.5492/wjccm.v10.i5.260
Subject(s) - medicine , multiple organ dysfunction syndrome , sepsis , observational study , immunosuppression , major trauma , organ dysfunction , immunology , intensive care unit , intensive care medicine , medline , sofa score , systemic inflammatory response syndrome , immune dysfunction , immune system , surgery , political science , law
Immune dysfunction following major traumatic injury is complex and strongly associated with significant morbidity and mortality through the development of multiple organ dysfunction syndrome (MODS), persistent inflammation, immunosuppression, and catabolism syndrome and sepsis. Neutrophils are thought to be a pivotal mediator in the development of immune dysfunction.