Open AccessSuccess of targeted transperineal biopsy in patients on surveillance for grade group 1 prostate cancer
Author(s) -
Kevin Martell,
Hans T. Chung,
Gerard Morton,
Danny Vesprini,
ChiaLin Tseng,
Ewa Szumacher,
Patrick Cheung,
Will Chu,
Stanley K. Liu,
Andrew Loblaw
Publication year - 2022
Publication title -
canadian urological association journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.477
H-Index - 38
eISSN - 1920-1214
pISSN - 1911-6470
DOI - 10.5489/cuaj.7752
Subject(s) - medicine , biopsy , prostate cancer , logistic regression , nodule (geology) , odds ratio , radiology , magnetic resonance imaging , prostate , prostate biopsy , cancer , paleontology , biology
We aimed to determine the minimum cross-sectional ellipsoid area on magnetic resonance (MR) of intraprostatic nodules that best predicts for subsequent targeted biopsies revealing ≥ grade group (GG) 2 disease.Methods: Forty-six patients previously diagnosed with GG 1 prostate adenocarcinoma who received cognitively fused, MR-guided, transperineal targeted biopsies in addition to six random biopsies were included in this analysis. A Youden cutpoint analysis was used to determine the ellipsoid area in the axial plane best predicting for ≥GG 2 disease within the targeted biopsy cores and logistic regression used to assess the result.Results: Median time from MR imaging to targeted biopsy was 2.4 (1.4–5.5) months. Forty of 46 (87%) patients had one nodule and 6/46 (13%) had two separate nodules on MR that received targeted biopsy. Of the 52 nodules, five (10%), 33 (63%), and 14 (27%) were Prostate Imaging–Reporting and Data System (PI-RADS) 3, 4, and 5. Thirteen (25%), six (12%), and 33 (64%) were in the anterior, medial, and posterior regions of the prostate. Median area was 0.72 (0.49–1.29) cm2 (average diameter 9.5 mm). Fifteen of 46 (33%) patients had ≥1 random biopsy and 20/52 (38%) nodules had ≥1 targeted biopsy revealing ≥GG 2 disease. The optimal area cutpoint was ≥0.7cm2, with an area under the curve of 0.671 (0.510–0.832). On logistic regression, areas ≥0.7 cm2 was solely predictive of targeted biopsy revealing ≥GG 2 disease (odds ratio 6.5, 1.3–32.4, p=0.022).Conclusions: Nodule area ≥0.7 cm2 may predict for transperineal-based targeted biopsies being positive for ≥GG 2 disease when 1–2 cores are taken.