Open AccessSimultaneous pancreas-kidney transplantation: Early complications and long-term outcomes – a single-centre experience
Author(s) -
Natalia Vidal Crespo,
P. López Cubillana,
P.Á. López González,
C. Moreno Alarcón,
Juan González Hernández,
Laura Martínez,
Alicia López Abad,
Juan C Fernández Garay,
Rocío Martínez Muñoz,
Santiago Llorente Viñas,
Juan Ángel Fernández Hernández,
G. Gómez Gómez
Publication year - 2022
Publication title -
canadian urological association journal
Language(s) - English
Resource type - Journals
eISSN - 1920-1214
pISSN - 1911-6470
DOI - 10.5489/cuaj.7635
Subject(s) - medicine , term (time) , pancreas transplantation , kidney transplantation , transplantation , intensive care medicine , general surgery , surgery , physics , quantum mechanics
This study aimed to assess the prevalence and severity of complications after simultaneous pancreas-kidney transplantation (SPKT) and to evaluate its influence on both grafts’ long-term results.Methods: This was an observational, retrospective study including 39 consecutive SPKT cases from 2000–2018. Complications were classified into kidney-related and pancreas-related. The severity of complications was assessed using the modified Clavien-Dindo scale. Kaplan-Meier curve analysis and log-rank tests were used. Cox regression was performed for the multivariate analysis.Results: All 39 recipients had long-term type I diabetes. Twenty-one (53.8%) patients suffered a Clavien-Dindo ≥IIIa complication. Most complications were pancreas-related, with 17 (43.6%) patients suffering from one. Kidney-related major complications were seen in 11 (28.2%) patients. Patient survival at one, five, and 15 years was 89.7%, 87.1%, and 83.9%, respectively; kidney survival was 87.1%, 81.4%, and 73.6%, respectively; and pancreas survival was 76.9%, 71.3%, and 72%, respectively. Pancreas graft survival was influenced by the presence of major postoperative complications; patients and kidney graft survival were not.Conclusions: Complications after SPKT influence pancreas graft survival. Despite the high rate of complications, our results suggest that patients' and kidney graft survival may not be affected by complications.