Open AccessPatients treated for uric acid stones reoccur more often and within a shorter interval in comparison to patients treated for calcium stones
Author(s) -
Amihay Nevo,
Oleg Levi,
Avner Sidi,
Alexander Tsivian,
Jack Baniel,
David Margel,
David A. Lifshitz
Publication year - 2019
Publication title -
canadian urological association journal
Language(s) - English
Resource type - Journals
eISSN - 1920-1214
pISSN - 1911-6470
DOI - 10.5489/cuaj.6259
Subject(s) - medicine , interquartile range , hazard ratio , percutaneous nephrolithotomy , uric acid , calcium oxalate , proportional hazards model , kidney stones , surgery , urology , ureteroscopy , calcium , confidence interval , gastroenterology , ureter , percutaneous
We aimed to investigate the association between stone composition and recurrence rate in a well-characterized group of patients.
Methods: From our prospectively assembled database of 1328 patients undergoing ureteroscopy and percutaneous nephrolithotomy (PCNL) between 2010 and 2015, we identified 457 patients who met the inclusion criteria: a minimum of two years' followup, stone-free status following surgery, normal anatomy, and FT-IR stone analysis results. Stone recurrence was identified by kidney-ureter-bladder (KUB) or an ultrasound (US). All symptomatic events were recorded. Kaplan-Meier and Cox proportional hazard regression methods were used to assess the differences in recurrence rates and associated risk factors.
Results: Calcium oxalate (CaOx), uric acid (UA), and struvite stones were found in 298 (65.2%), 99 (21.7%), and 28 (6.1%) patients, respectively. During a median followup of 38 months (interquartile range [IQR] 31–48), stone recurred in 111 (24%) patients. One-year stone-free rates stratified by composition were: CaOx 98%, UA 91.9%, calcium phosphate 90%, struvite 88%, and, cystine 83%; the two-years stone-free rates were 92.6%, 82.7%, 80%, 73%, and 75%, respectively. On multivariate Cox regression analysis, UA composition, the absence of medical preventive therapy, and preoperative stone burden were associated with a shorter time to recurrence. Secondary intervention for recurrent, symptomatic stones was required in 11 (11.1%) and 22 (7.4%) of patients with UA and CaOx stones, respectively (p=0.02).
Conclusions: UA stone-formers are more likely to have a recurrence and to undergo surgical intervention in comparison to CaOx stone-formers, regardless of MPT. These differences are more prominent during the first year of followup and should be incorporated into the patient's followup protocol.