Open AccessAn ALK translocation positive carcinoma of the lung presenting as uremia due to bilateral
Author(s) -
Shilo Rosenberg,
Ran Katz,
Dov Pode,
N. Ofer Gofr
Publication year - 2013
Publication title -
canadian urological association journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.477
H-Index - 38
eISSN - 1920-1214
pISSN - 1911-6470
DOI - 10.5489/cuaj.172
Subject(s) - crizotinib , medicine , lung , adenocarcinoma , pathology , retroperitoneal space , carcinoma , adenocarcinoma of the lung , lung cancer , oncology , radiology , cancer , malignant pleural effusion
We describe an unusual presentation of metastatic lung adenocarcinoma as malignant retroperitoneal fibrosis (MRPF). The diagnostic challenge, due to the small solitary lung mass and absence of a discrete retroperitoneal mass, was overcome by diagnostic laparoscopy. Molecular analysis of tissue acquired was positive for ALK gene rearrangement. Treatment of the patient with crizotinib reversed MRPF. He was weaned off the nephrostomy tubes and is with stable renal function 11 months after diagnosis.