Open AccessGenitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature
Author(s) -
Shilo Lefresne,
Alysa Fairchild,
Royce H. Johnson,
Jean Deschênes,
Laurie Russell,
John M. Pederson
Publication year - 2012
Publication title -
canadian urological association journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.477
H-Index - 38
eISSN - 1920-1214
pISSN - 1911-6470
DOI - 10.5489/cuaj.163
Subject(s) - medicine , genitourinary system , malignancy , prostate cancer , prostate , enucleation , prostate specific antigen , orbit (dynamics) , metastasis , radiology , lower urinary tract symptoms , oncology , pathology , cancer , surgery , engineering , aerospace engineering
Metastases to the eye or orbit as the initial presentation of genitourinary malignancy are unusual and can be a diagnostic challenge. We report an 81-year-old man who presented with pain and proptosis in an eye that had been blind for 50 years. Radiologic investigations identified a mass involving the left globe and orbit. Histology of the enucleation specimen was consistent with a metastatic poorly differentiated carcinoma suggestive of a prostate primary. With the constellation of obstructive urinary symptoms, an abnormal digital rectal examination, elevated prostate-specific antigen and a positive bone scan, androgen deprivation therapy was initiated for metastatic prostate cancer. After an initial response to treatment, the patient’s disease progressed in a manner atypical for prostate cancer. After describing our case, we review the literature on ocular and orbital metastases and their relation to genitourinary malignancies.