Open AccessParaneoplastic production of heparin-like anticoagulant in a patient with metastatic transitional cell carcinoma
Author(s) -
Kelly N. Fahl,
Stephen A. Poon,
Ketan K. Badani,
Mitchell C. Benson
Publication year - 2013
Publication title -
canadian urological association journal
Language(s) - English
Resource type - Journals
eISSN - 1920-1214
pISSN - 1911-6470
DOI - 10.5489/cuaj.1165
Subject(s) - medicine , transitional cell carcinoma , heparin , metastasis , anticoagulant , coagulopathy , carcinoma , cancer , pathology , oncology , bladder cancer
It has been reported that patients with bladder cancer have widelyvarying paraneoplastic consequences, including metabolic, dermatologic,myopathic and neurologic disturbances. We report a case of a52-year-old man with advanced transitional cell carcinoma and livermetastases, who developed a severe coagulopathy following roboticradical cystoprostatectomy due to circulating heparin-like substancesprior to onset of liver failure. Heparin-like anticoagulant production isa rare paraneoplastic effect documented in concert with transitionalcell carcinoma, breast carcinoma and hematological malignancies.