Antifungal Effect of Brachyglottis repanda Ethanol Extract | Zendy

Chan-Nam Yook | Zendy; Young-Soon Na | Zendy; Hwa-Jung Choi | Zendy; Il-Soo You | Zendy; Jong Min Baek | Zendy; Seung-Hwa Baek | Zendy

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Antifungal Effect of Brachyglottis repanda Ethanol Extract

Author(s) -

Chan-Nam Yook,

Young-Soon Na,

Hwa-Jung Choi,

Il-Soo You,

Jong Min Baek,

Seung-Hwa Baek

Publication year - 2010

Publication title -

toxicological research

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.872

H-Index - 30

eISSN - 2234-2753

pISSN - 1976-8257

DOI - 10.5487/tr.2010.26.2.117

Subject(s) - cytotoxic t cell , ethanol , chemistry , antifungal , in vitro , fungus , ic50 , trichophyton , traditional medicine , pharmacology , biology , microbiology and biotechnology , biochemistry , medicine , botany

The crude ethanol extract of B. repanda showed the cytotoxic activity against Polio virus (25% activity at 150 μg/disk) and the minor cytotoxic activity against BSC cells (African green monkey kidney) . However, the crude ethanol extract of B. repanda was non-toxic to murine leukaemia cells CCL 46 P388D1 (IC50, > 62,500 ng/ml) . Cytotoxic and antifungal activities were strongly shown by Fr. 64-3 which was eluted with 90% CH3CN/H2O, 100% CH3CN, and 50% CH3CN/H2O (SM 2 at 150 μg/disk) . The fraction 64-3 also showed the most cytotoxic activity against murine leukaemia cells (128 mg, IC50 10,051 ng/ml at 75 μg/disk) . These results suggest that this fraction has a potent antifungal activity against the dermatophytic fungus Trichophyton mentagrophytes ATCC 28185.

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