Open AccessIncreased Gene Expression in Cultured BEAS-2B Cells Treated with Metal Oxide Nanoparticles
Author(s) -
Eun-Jung Park,
Kwangsik Park
Publication year - 2009
Publication title -
toxicological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.872
H-Index - 30
eISSN - 2234-2753
pISSN - 1976-8257
DOI - 10.5487/tr.2009.25.4.195
Subject(s) - nanoparticle , metal , gene expression , chemistry , microbiology and biotechnology , gene , nanotechnology , biology , materials science , biochemistry , organic chemistry
Recent publications showed that metal nanoparticles which are made from TiO 2 , CeO 2 , Al 2 O 3 , CuCl 2 , AgNO 3 and ZnO 2 induced oxidative stress and pro-inflammatory effects in cultured cells and the responses seemed to be common toxic pathway of metal nanoparticles to the ultimate toxicity in animals as well as cellular level. In this study, we compared the gene expression induced by two different types of metal oxide nanoparticles, titanium dioxide nanoparticles (TNP) and cerium dioxide nanoparticles (CNP) using microarray analysis. About 50 genes including interleukin 6, interleukin 1, platelet-derived growth factor β, and leukemia inhibitory factor were induced in cultured BEAS-2B cells treated with TNP 40 ppm. When we compared the induction levels of genes in TNP-treated cells to those in CNP-treated cells, the induction levels were very correlated in various gene categories (r = 0.645). This may suggest a possible common toxic mechanism of metal oxide nanoparticles.