Open AccessThe subcellular distribution of MnSOD alters during sodium selenite-induced apoptosis
Author(s) -
Lina Guan,
Qian Jiang,
Zhushi Li,
Fang Huang,
Yu Ren,
Yang Yang,
Caimin Xu
Publication year - 2009
Publication title -
bmb reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.511
H-Index - 77
eISSN - 1976-670X
pISSN - 1976-6696
DOI - 10.5483/bmbrep.2009.42.6.361
Subject(s) - selenium , superoxide dismutase , chemistry , mitochondrion , hydrogen peroxide , superoxide , cytosol , reactive oxygen species , subcellular localization , mitochondrial matrix , apoptosis , sodium , biochemistry , intracellular , antioxidant , enzyme , microbiology and biotechnology , biophysics , biology , cytoplasm , organic chemistry
It was reported that high doses of sodium selenite can induce apoptosis of cancer cells, but the molecular mechanisms are poorly understood. Manganese superoxide dismutase (MnSOD) converts superoxide radical to hydrogen peroxide within the mitochondrial matrix and is one of the most important antioxidant enzymes. In this study, we showed that 20 microM sodium selenite could alter subcellular distribution of MnSOD, namely a decrease in mitochondria and an increase in cytosol. The alteration of subcellular distribution of MnSOD is dependent on the production of superoxide induced by sodium selenite.