Open Access3D Lipidic Matrix for Incorporation and Stabilization of Biologically Active Molecules
Author(s) -
Martina Zatloukalová
Publication year - 2022
Publication title -
chemické listy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.137
H-Index - 28
eISSN - 1213-7103
pISSN - 0009-2770
DOI - 10.54779/chl20220172
Subject(s) - lyotropic , bioavailability , amphiphile , lyotropic liquid crystal , aqueous solution , biological activity , molecule , biomolecule , solubility , hexagonal phase , chemistry , hexagonal crystal system , amphiphilic molecule , organic chemistry , phase (matter) , matrix (chemical analysis) , chemical engineering , materials science , nanotechnology , combinatorial chemistry , liquid crystalline , chromatography , crystallography , biochemistry , polymer , in vitro , copolymer , bioinformatics , engineering , biology
In aqueous media, biologically active substances are usually unstable, poorly soluble compounds with low bioavailability. Incorporation of these compounds into the structure of lipid-based lyotropic liquid crystalline phase or nanoparticles can increase their solubility and subsequent bioavailability. The aim of this review is to clarify the principle of self-assembly of lipidic amphiphilic molecules in the aqueous environment, to present lipid bicontinuous cubic and hexagonal phases and their current biological application.