Elevated Antibodies to Oxidized Low Density Lipoprotein are Positively Related with a Severity of Coronary Artery Disease | Zendy

Elmir Jahić | Zendy; Fahir Baraković | Zendy; Zumreta Kušljugić | Zendy; Farid Ljuca | Zendy; Jasmiurkić | Zendy; Midhat Nurkić | Zendy; Larisa DizdarevićHudić | Zendy; Elnur Smajić | Zendy

Open Access

Elevated Antibodies to Oxidized Low Density Lipoprotein are Positively Related with a Severity of Coronary Artery Disease

Author(s) -

Elmir Jahić,

Fahir Baraković,

Zumreta Kušljugić,

Farid Ljuca,

Jasmiurkić,

Midhat Nurkić,

Larisa DizdarevićHudić,

Elnur Smajić

Publication year - 2010

Publication title -

acta medica saliniana

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.105

H-Index - 4

eISSN - 1840-3956

pISSN - 0350-364X

DOI - 10.5457/ams.120.10

Subject(s) - coronary artery disease , medicine , cardiology , antibody , low density lipoprotein , lipoprotein , cholesterol , immunology

Aim: The prognostic value of circulating antibodies to oxidized low-density lipoprotein (anti-oxLDL) in patients with coronary heart disease is not completely clear. We aimed to investigate the association between levels of anti-oxLDL in three groups of patients with different grades of severity of coronary heart disease. Patients and methods: The study included 101 patients classified into three groups: one (N=35) with acute myocardial infarction (AMI), a group (N=35) with angiographicallly proven coronary artery disease (APCAD), and a group without angiographicallly proven coronary artery disease (N=31) designated as a control group. Levels of IgG anti-oxLDL antibodies were meausured by enzyme-linked immunosorbent assay. Results: Mean anti-oxLDL value was significantly higher in patients with AMI than in patients with APCAS (1342.1±581.5 mIU/ml vs. 553.0±183.3 mIU/ml, p<0.001), as well as compared with control group (1342.1±581.5 mIU/ml vs. 246.5±114.3, p<0.001). Similarly, significant difference in anti-oxLDL levels was found between the patients with APCAS and control group (p<0.001). Conclusions: The present study showed that elevated levels of anti-oxLDL are positively related with a severity of coronary artery disease. Hence, elevated levels of anti-oxLDL may identify patients with unstable coronary heart disease. Oxidized LDL in circulating plasma could serve as a marker of cardiovascular events

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