Open AccessDosage variability of veterinary drug products, containing furosemide, linked to tablet splitting
Author(s) -
Lauretta Maggi,
Valeria Friuli,
Paola Perugini,
G. Musitelli,
Luigi Venco
Publication year - 2021
Publication title -
open veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.39
H-Index - 10
eISSN - 2226-4485
pISSN - 2218-6050
DOI - 10.5455/ovj.2021.v11.i3.21
Subject(s) - furosemide , bioavailability , diuretic , drug , pharmacology , dissolution , distribution (mathematics) , pharmacokinetics , medicine , dissolution testing , in vitro , chemistry , mathematics , biochemistry , mathematical analysis , biopharmaceutics classification system
Furosemide is a potent diuretic drug widely used to treat congestive heart failure in dogs and cats, but it shows remarkable variability in bioavailability and efficacy when administered orally. In particular, a different diuretic effect can be detected after repeated administrations of the same medicinal product in the same animal. For this reason, we investigate the possible reasons for this peculiar behavior. Drug products for veterinary andhuman use are compared in terms of variability for tablet splitting, in vitro dissolution profiles (in different fluids that could simulate the gastrointestinal environment of pets), and drug distribution uniformity.