Open AccessAcquired myasthenia gravis with concurrent polymyositis and myocarditis secondary to a thymoma in a dog
Author(s) -
R Perillo,
Marika Menchetti,
Pasquale A Giannuzzi,
Angela Marchiori,
M. Rondena,
Stefania Gasparini
Publication year - 2021
Publication title -
open veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.39
H-Index - 10
eISSN - 2226-4485
pISSN - 2218-6050
DOI - 10.5455/ovj.2021.v11.i3.16
Subject(s) - thymoma , myasthenia gravis , medicine , polymyositis , myocarditis , pathology , pyridostigmine
Canine thymomas are associated with multiple paraneoplastic syndromes, among which myasthenia gravis (MG) is the most common. Acquired MG is an autoimmune disease characterized by the presence of antibodies against acetylcholine receptors (ACHRs). ACHRs antibodies are the most commonly formed, but the production of antistriational antibodies binding to skeletal and cardiac muscle proteins has also been recorded both in humans and dogs. An association between the occurrence of antistriational antibodies and a severe form of myocarditis, giant cell myocarditis, has been described in humans.