Open AccessEnhancement of natural killer cell activity by oral administration of a fermented soybean product in dogs
Author(s) -
Shoma Mikawa,
Akira Matsuda,
Yasuyuki Kamemori,
Satoru Asanuma,
Hitoshi Kitagawa
Publication year - 2021
Publication title -
open veterinary journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.39
H-Index - 10
eISSN - 2226-4485
pISSN - 2218-6050
DOI - 10.5455/ovj.2021.v11.i3.10
Subject(s) - peripheral blood mononuclear cell , immune system , cytotoxic t cell , cellular immunity , immunology , oral administration , cd8 , nattokinase , biology , pharmacology , medicine , in vitro , food science , fermentation , biochemistry
Probiotics are known for their ability to enhance cellular immunity, including the activation of macrophages, natural killer (NK) cells, and cytotoxic T lymphocytes. Natto is a Japanese traditional probiotic food made by fermenting soybean with bacteria Bacillus subtilis var. natto . Components of natto include spores of B. subtilis natto , poly-γ-glutamic acid, and levan, which have demonstrated their immunoadjuvant and anti-allergic effects through various in vitro and in vivo studies. However, it remains unclear whether oral administration of natto can modulate the immune activity in animals.