Open AccessErythropoietin Effect on Testicular Germinal Epithelium Cells in Undescended Testis Mice Model
Author(s) -
Astarin Ardiani,
Basuki Bambang Purnomo,
S. Kurnia Penta,
A. Kenty Wantri,
Viera Wardhani
Publication year - 2021
Publication title -
medicinski arhiv
Language(s) - English
Resource type - Journals
eISSN - 1986-5961
pISSN - 0350-199X
DOI - 10.5455/medarh.2021.75.168-173
Subject(s) - germinal epithelium , erythropoietin , spermatogenesis , andrology , anti müllerian hormone , orchiopexy , biology , medicine , hormone , gynecology , endocrinology , surgery
Undescended testis is an absence of testis in the scrotum, the incidence was 15 cases per 1000 from 1974 to 1996 in Europe. At Saiful Anwar Regional Hospital East Java, from January 2015 to July 2019 there were 60 boys diagnosed with undescended testis. A temperature rise of testis located in the abdominal triggers production of reactive oxygen species, causing impairment of the testicular epithelial germ cells and spermatogenesis, leading to many complications. Erythropoietin is a glycoprotein hormone that circulates in the body and has a positive effect on ischemic injury/gonadal reperfusion.