Open AccessMesenchymal Stem Cells Suppress TGF-beta Release to Decrease and #945;-SMA Expression in Ameliorating CCl4-Induced Liver Fibrosis
Author(s) -
Dedy Hermansyah,
Agung Putra,
Adi Muradi Muhar,
Retnaningsih Retnaningsih,
Ken Wirastuti,
Bayu Tirta Dirja
Publication year - 2021
Publication title -
medicinski arhiv
Language(s) - English
Resource type - Journals
eISSN - 1986-5961
pISSN - 0350-199X
DOI - 10.5455/medarh.2021.75.16-22
Subject(s) - mesenchymal stem cell , ccl4 , intraperitoneal injection , hepatic stellate cell , carbon tetrachloride , extracellular matrix , chemistry , fibrosis , endocrinology , sma* , transforming growth factor , medicine , immunohistochemistry , transforming growth factor beta , pathology , biochemistry , mathematics , organic chemistry , combinatorics
Liver fibrosis (LF) is the excessive deposition of extracellular matrix (ECM), produced by overactivated hepatic stellate cells, following prolonged transforming growth factor-β (TGF-β) stimulation. The ability of mesenchymal stem cells (MSCs) to improve LF has been reported. However, the mechanisms of MSCs to ameliorate LF through suppressing TGF-β and α-smooth muscle actin (α-SMA) remains unclear.